ANKMJ
Ankyra Medical Journal

Ankyra Medical Journal (AnkMJ), formerly known as the Journal of Translational and Practical Medicine, regularly publishes international quality issues in the field of Medicine in the light of current information.

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Original Article
The relationship between zinc status and inflammatory marker levels in FMF
Abstract
Aims: This study aimed to evaluate serum zinc concentrations in individuals diagnosed with FMF and to explore whether zinc status may influence the inflammatory episodes characteristic of the disease.
Methods: We retrospectively reviewed the medical records of patients with FMF, who were under the follow-up of our nephrology-rheumatology center between 2018 and 2025.
Results: One hundred twelve FMF patients (M/F=52/60) with a mean age of 11.9±5.1 years were included in this study. 35 (31.3%) of the patients have compound heterozygous mutation and 77 (68.8%) have heterozygous mutation. There was no difference in mean of leucocyte count and zinc level between these mutation groups. The mean pre-treatment sedimentation was signifanctly higher in patients with frequent attacks (p=0.021). However there was no difference between the attack frequency groups in mean of gender age, both of pre and post-treatment CRP, zinc, leucocyte count and post- treatment sedimentation.(p>0.05). There was a positive correlation between mean zinc and mean leucocyte, CRP levels (p=0.019, r=0.334 and p=0.016,r=0.344 respectiely), but not with sedimentation.
Conclusion: Notably, in our current study, while zinc level correlate with inflammatory markers, serum zinc levels demonstrated a significant relationship with them.

Keywords : Familial mediterranean fever, zinc, inflammation, C-reactive protein, leukocyte count, pediatric rheumatology

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Article available in :
Volume 4, Issue 4, 2025
Page : 85-87
https://doi.org/10.51271/ANKMJ-0054
Article Information
Received : 13 Tem 2025
Accepted : 18 Eki 2025
Published : 19 Eki 2025
Corresponding Author :

Ayşegül Alpcan: Department of Pediatrics, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkiye

[email protected]
Citation : Uysal A, Kandur Y, Gürkan M, Pek ME, Şanlı C, Alpcan A. The relationship between zinc status and inflammatory marker levels in FMF. Ank Med J. 2025;4(4):85-87.

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