ANKMJ
Ankyra Medical Journal

Ankyra Medical Journal (AnkMJ), formerly known as the Journal of Translational and Practical Medicine, regularly publishes international quality issues in the field of Medicine in the light of current information.

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Case Report
Ocular manifestations of atypical hemolytic uremic syndrome: a case report
Abstract
Atypical hemolytic uremic syndrome (aHUS) is a rare but serious condition that is often associated with renal impairment and thrombotic microangiopathy. This case report presents the case of a 20-year-old female with a long-standing diagnosis of aHUS who developed hypertensive choroidopathy, a rare ocular manifestation. The patient presented with sudden-onset hypertension and visual disturbances, with a blood pressure of 270/120 mmHg. Ophthalmological examination revealed bilateral papilledema, Elschnig spots, and Siegrist streaks, indicative of hypertensive choroidopathy. Imaging studies, including fundus photography, fluorescein angiography, and optical coherence tomography (OCT), confirmed retinal findings and optic disc edema. This case emphasizes the critical need for early detection and regular ophthalmological monitoring in aHUS patients, as ocular changes, such as hypertensive choroidopathy, can be early indicators of systemic complications. Early intervention, including blood pressure management, is essential for preventing irreversible damage to vision. This report underscores the importance of an integrated multidisciplinary approach to managing aHUS, especially considering the systemic nature of the disease and its potential ocular implications.

Keywords : Hypertensive choroidopathy, papilledema, atypical hemolytic uremic syndrome, Siegrist streaks, Elschnig spots

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1. Fidan K, Goknar N, Gulhan B, et al. Extra-Renal manifestations of atypical hemolytic uremic syndrome in children. Pediatr Nephrol. 2018; 33(8):1395-1403. doi:10.1007/s00467-018-3933-3
2. Formeck C, Swiatecka-Urban A. Extra-renal manifestations of atypical hemolytic uremic syndrome. Pediatr Nephrol.2019 ;34(8):1337-1348. doi:10.1007/s00467-018-4039-7
3. Yerigeri K, Kadatane S, Mongan K, et al. Atypical hemolytic-uremic syndrome: genetic basis, clinical manifestations, and a multidisciplinary approach to management. J Multidiscip Healthc.2023;16:2233-2249. doi:10.2147/JMDH.S245620
4. Avila A, Cao M, Espinosa M, Manrique J, Morales E. Recommendations for the individualised management of atypical hemolytic uremic syndrome in adults<strong>. </strong>Front Med (Lausanne). 2023<strong>;</strong>10:1264310. doi:10. 3389/fmed.2023.1264310
5. Polito MS, Machetta F, Fea AM, Eandi CM. Hypertensive choroidopathy in atypical hemolytic-uremic syndrome. Eur J Ophthalmol. 2021;31(2):NP63-NP66. doi:10.1177/1120672119896286
6. Ugarte M, Horgan S, Rassam S, Leong T, Kon CH. Hypertensive choroidopathy: recognizing clinically significant end-organ damage. Acta Ophthalmol.2008;86(2):227-228.doi:10.1111/j.1600-0420.2007. 01030.x
7. Perlman J, Hines E. Systemic diseases with retinal involvement. In: Ophthalmic Pathology: An Atlas and Texbook, Vol 2. WB Saunders; 1985.
8. Hayreh SS, Podhajsky PA, Zimmerman B. Ocular manifestations of giant cell arteritis. Am J Ophthalmol. 1998;125(4):509-520. doi:10.1016/s0002-9394(99)80192-5
Article available in :
Volume 4, Issue 3, 2025
Page : 62-65
https://doi.org/10.51271/ANKMJ-0049
Article Information
Received : 19 May 2025
Accepted : 02 Tem 2025
Published : 29 Tem 2025
Corresponding Author :

Hatice Zeynep İlikli: Department of Ophthalmology, Ankara Etlik City Hospital, Ankara, Turkiye

[email protected]
Citation : İlikli HZ, Teke MY. Ocular manifestations of atypical hemolytic uremic syndrome: a case report. Ank Med J. 2025;4(3):62-65.

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