ANKMJ
Ankyra Medical Journal

Ankyra Medical Journal (AnkMJ), formerly known as the Journal of Translational and Practical Medicine, regularly publishes international quality issues in the field of Medicine in the light of current information.

eISSN: 3023-655X
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Online Manuscript System

Index
Original Article
Investigation of Staphylococcus aureus nasal carriage rates in hemodialysis patients
Abstract
Aims: The aim of this study was to determine the rates of nasal carriage of Staphylococcus aureus (S. aureus) in patients undergoing hemodialysis and the susceptibilities to mupirocin and fusidic acid in patients with nasal carriage of S.aureus.
Methods: A total of 165 hemodialysis patients, 55 (33.3%) females and 109 (66.03%) males, were included in the study. Nasal swab samples obtained from the patients were inoculated on mannitol-salt agar (Beslab, Turkey) medium. The media were incubated in an oven at 37 °C for 72 hours. Methicillin resistance was determined on Mueller-Hinton agar medium with cefoxitin disk (Bioanalyse, Turkey) and mupirocin and fusidic acid susceptibilities were determined by disk diffusion method with the discs of these antibiotics (Bioanalyse, Turkey).
Results: S. aureus nasal carriage was detected in a total of 14 (8.48%) patients, 9 (5.45%) of whom had methicillin-sensitive S. aureus (MSSA) nasal carriage and 5 (3.03%) had methicillin-resistant S. aureus (MRSA) nasal carriage. Of a total of 5 MRSA strains, 1 was resistant to mupirocin and 1 was resistant to fusidic acid. Of a total of 9 MSSA strains, 2 were resistant to mupirocin and 2 were resistant to fusidic acid. It was determined that mupirocin and fusidic acid resistance was higher in MSSA strains.
Conclusion: In our study, the rate of S. aureus nasal carriage in hemodialysis patients was found to be low. In addition, the resistance rates of MSSA strains to mupirocin and fusidic acid, which are topical antibiotics that can be used in the eradication of S.aureus nasal carriage, were higher than the resistance rates of MRSA strains to mupirocin and fusidic acid. We think that planning the eradication of nasal carriage in dialysis patients according to mupirocin and fusidic acid susceptibility results will increase the eradication success.

Keywords : Hemodialysis patients, nasal carriage, Staphylococcus aureus, mupirocin, fusidic acid

Download Article


1. Çifci A, Erol ÖÖ, Kaya Ç, Ergen E, Cesur S. Hemodiyaliz hastalarında MRSA burun taşıyıcılığı ve VRE rektal taşıyıcılığı oranlarının belirlenmesi. Ortadoğu Tıp Derg. 2013;5(4):214-218.
2. Berns JS. Infection with antimicrobial-resistant microorganisms in dialysis patients. Semin Dial. 2003;16(1):30-37.
3. Kluytmans JA, Belkum AV, Verbrugh H. Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin Microbiol Rev. 1997;10(3):505-520.
4. Kluytmans J, Harbarth S. Methicillin-resistant Staphylococcus aureus decolonization: "yes, we can," but will it help? Infect Control Hosp Epidemiol. 2009;30(7):633-635.
5. Çelik G, Gülcan A. Hemodiyaliz tedavisi alan hastalarda nazal Staphylococcus aureus taşıyıcılığı ve risk faktörlerinin belirlenmesi. Türk Mikrobiyol Cem Derg. 2010;40(2):79-86.
6. Şencan İ, Kaya D, Atakoğlu N, Şahin İ, Bahtiyar Z, Yıldırım M. Hemodiyaliz hastalarında burunda Staphylococcus aureus taşıyıcılığı. İnfeksiyon Derg. 2003;17:31-34.
7. Lu PL, Tsai JC, Chiu YW, et al. Methicillin resistant Staphylococcus aureus carriage, infection and transmission in dialysis patients, healthcare workers and their family members. Nephrol Dial Transplant. 2008;23(5):1659-1665.
8. Lederer SR, Riedelsdorf G, Schiffl H. Nasal carriage of Staphylococcus aureus: the prevalence, patients at risk and the effect of elimination on outcomes among outclinic haemodialysis patients. Eur J Med Res. 2007; 12(7):284-288.
9. Cesur S, Ertürk Ş, Nergizoglu G, Tekeli E. Hemodiyaliz hastaları ve personelinde burunda Staphylococcus aureus taşıyıcılığı. İnfeks Derg. 2004;18(1):49-52.
10. Cesur S, Kurşun Ö, Aylı D, et al. Ayaktan takip edilen hemodiyaliz hastalarında Staphylococcus aureus nazal taşıyıcılığı oranları ve izole edilen suşların mupirosin, fusidik asit, trimetoprim-sulfametoksazol duyarlılıkları. Ortadoğu Tıp Derg. 2016;8(4):177-181.
11. Kurutepe S, Gaz H, Sürücüoğlu S, Aktaş E, Özbakkaloğlu B. Klinik ve pre-klinik hastane personelinde metisiline direncli Staphylococcus aureus burun taşıyıcılık oranları. Türk Mikrobiyol Cem Derg. 2005; 35(3):178-182.
12. Mutlu B, Gündeş S, Kolaylı , et al. Hastane personelinin burun kültürlerinden izole edilen stafilokok türlerinin metisilin duyarlılığı. Klimik Derg. 2001;14(3):159-160.
13. Schmid H, Romanos A, Schiffl H, Lederer SR. Persistent nasal methicillin-resistant Staphylococcus aureus carriage in hemodialysis outpatients: a predictor of worse outcome. BMC Nephrol. 2013;14(1):93. doi:10.1186/1471-2369-14-93
14. Scheuch M, Freiin von Rheinbaben S, Kabisch A, et al. Staphylococcus aureus colonization in hemodialysis patients: a prospective 25 months observational study. BMC Nephrol. 2019;20(1):153. doi:10.1186/s12882-019-1332-z
15. Lafrance JP, Rahme E, Lelorier J, Iqbal S. Vascular access-related infections:definitions, incidence rates, and risk factors. Am J Kidney Dis. 2008;52(5):982-993.
Article available in :
Volume 4, Issue 1, 2025
Page : 5-8
https://doi.org/10.51271/ANKMJ-0036
Article Information
Received : 18 Kas 2024
Accepted : 25 Ara 2024
Published : 06 Oca 2025
Corresponding Author :

Hakkı Öztürk: Infectious Diseases Epidemiologist, Private Ankara Dialysis Center, Ankara, Turkiye

[email protected]
Citation : Öztürk H, Özsoy M. Investigation of Staphylococcus aureus nasal carriage rates in hemodialysis patients Staphylococcus aureus nasal carriage in hemodialysis patients. Ank Med J. 2025;4(1):5-8.

Read: 22
Cited: 0
Download : 42
_Footer