ANKMJ
Ankyra Medical Journal

Ankyra Medical Journal (AnkMJ), formerly known as the Journal of Translational and Practical Medicine, regularly publishes international quality issues in the field of Medicine in the light of current information.

eISSN: 3023-655X
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Original Article
Evaluation of the relationship between gastroesophageal reflux disease and glycogenic acanthosis
Abstract
Aims: This study aims to evaluate the possible etiologic factors, espacially GERD, in the presence of glycogenic acanthosis (GA).
Methods: A total of 387 patients who underwent upper gastrointestinal endoscopy between November 2023 and April 2024 were enrolled for the study. Participants were divided into two groups on the basis of the presence of GA. Groups were compared in terms of factors such as age, smoking, GERD, hiatal hernia, and helicobacter pylori.
Results: Group comparasion revealed no significant difference except the presence of hiatus hernia, and GERD which was observed higher in the GA (+) group (p <0.001, for both parameters). In terms of the identification of the predictors of GA positivity, univariate and multiple variate analysis were performed. Only GERD (OR: 7.628, 95% CI: 3.202-18.169, p < 0.001) and hiatus hernia (OR: 3.449, 95% CI: 1.387-8.579, p = 0.008) were demonstrated as independent predictors of GA positivity in the multiple variate analysis.
Conclusion: In this study, we demonstrated that GA may be associated with GERD and hiatal hernia.

Keywords : Gastroesophageal reflux disease, glycogenic acanthosis, hiatal hernia

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1. Fitzgibbons PL. Histochemistry in the diagnosis of non-neoplastic gastrointestinal disorders. <em>Semin Diagn Pathol.</em> 2018;35(6):370-380.
2. Boschee ED, Yap JY, Turner JM. Prediction of esophageal and gastric histology by macroscopic diagnosis during upper endoscopy in pediatric celiac disease. <em>World J Gastroenterol.</em> 2017;23(4):646-652.
3. Rywlin AM, Ortega R. Glycogenic acanthosis of the esophagus. <em>Arch Pathol</em>. 1970;90(5):439-443.
4. Tsai SJ, Lin CC, Chang CW, et al. Benign esophageal lesions: endoscopic and pathologic features. <em>World J Gastroenterol</em>. 2015;21(4):1091-1098.
5. Katz PO, Dunbar KB, Schnoll-Sussman FH, et al. ACG clinical guideline for the diagnosis and management of gastroesophageal reflux disease. <em>Am J Gastroenterol</em>. 2022;117(1):27-56.
6. Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. <em>Am J Gastroentero</em>. 2013;108(3):308-328.
7. Iwakiri K, Fujiwara Y, Manabe N, et al. Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2021. <em>J Gastroenterol</em>. 2022; 57(4):267-285.
8. Gyawali CP, Fass R. Management of gastroesophageal reflux disease. <em>Gastroenterology</em>. 2018;154(2):302-318.
9. Vadva MD, Triadafilopoulos G. Glycogenic acanthosis of the esophagus and gastroesophageal reflux. <em>J Clin Gastroenterol</em>. 1993;17(1):79-83.
10. Yılmaz N. The relationship between reflux symptoms and glycogenic acanthosis lesions of the oesophagus. <em>Prz Gastroenterol</em>. 2020;15(1):39-43.
11. Bender MD, Allison J, Cuartas F, et al. Glycogenic acanthosis of the esophagus: a form of benign epithelial hyperplasia. <em>Gastroenterology</em>. 1973; 65(3):373-380.
12. Glick SN, Teplick SK, Goldstein J, et al. Glycogenic acanthosis of the esophagus. <em>AJR Am J Roentgenol</em>. 982;139(4):683-688.
13. Ghahremani GG, Rushovich AM. Glycogenic acanthosis of the esophagus: radiographic and pathologic features. <em>Gastrointest Radiol</em>. 1984;9(2):93-98.
14. Rose D, Furth EE, Rubesin SE. Glycogenic acanthosis. <em>AJR Am J Roentgenol</em>. 1995;164(1):96.
15. Nazlig&uuml;l Y, Aslan M, Esen R, et al. Benign glycogenic acanthosis lesions of the esophagus. <em>Turk J Gastroenterol</em>. 2012;23(3):199-202.
16. Ikeda M, Kojima Y, Nakamura T, et al. Glycogenic acanthosis of the esophagus&mdash;an analysis of clinically relevant factors. <em>Dig Endosc</em>. 1993;5: 49-54.
17. EmirogluH,SokucuS,GulluogluM<em>, et al</em>. 684 glycogenic acanthosis of the esophagus: ıs it associated with <em>Helicobacter Pylori</em> ınfection in children? <em>Archives of Disease in Childhood.</em>2012;97<strong>:</strong>A197-A198.
18. İ Asaoka D, Nagahara A, Taniguchi G, et al. The clinical characteristics of glycogenic acanthosis. <em>Gastrointes Endosc. </em>2012; AB472-AB473.
19. Nason KS, Wichienkuer PP, Awais O, et al. Gastroesophageal reflux disease symptom severity, proton pump inhibitor use, and esophageal carcinogenesis.<em>Arch Surg</em>. 2011;146(7):851-858.
20. Maret-Ouda J, Markar SR, Lagergren J. Gastroesophageal reflux disease: a review.<em>JAMA</em>. 2020;324(24):2536-2547.
Article available in :
Volume 3, Issue 6, 2024
Page : 136-139
https://doi.org/10.51271/ANKMJ-0031
Article Information
Received : 20 Eki 2024
Accepted : 10 Kas 2024
Published : 13 Kas 2024
Corresponding Author :

İbrahim Ethem Güven: Department of Gastroenterology, Yenimahalle Training and Research Hospital, Ankara, Turkiye

[email protected]
Citation : Güven İE. Evaluation of the relationship between gastroesophageal reflux disease and glycogenic acanthosis. Ank Med J. 2024;3(6):136-139.

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