ANKMJ
Ankyra Medical Journal

Ankyra Medical Journal (AnkMJ), formerly known as the Journal of Translational and Practical Medicine, regularly publishes international quality issues in the field of Medicine in the light of current information.

eISSN: 3023-655X
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Original Article
Is the peripapillary area completely healthy in Stargardt disease?
Abstract
Aims: To evaluate the peripapillary retinal nerve fiber layer (pRNFL) thickness measured using spectral domain optical coherence tomography (SD-OCT) in patients with Stargardt disease (STGD).
Methods: This was a single-center cross-sectional case-control study. Twenty eyes with STGD were staged according to Fishman STGD classification. Peripapillary RNFL thickness was measured using Heidelberg Spectralis SD-OCT. The mean pRNFL thickness of the four quadrants (temporal, superior, nasal, and inferior) and all quadrants were compared with the mean pRNFL thickness from 20 eyes of age-matched healthy subjects.
Results: The mean age of Stargardt patients was 40.9 years (range, 18–59 years) and that of the control group was 40.6 years (range, 19–59 years). Twenty eyes (70%) had thinner pRNFL thickness in the temporal quadrant (mean: -7.55 µm, 95%CI -3 to -12 µm, 10% thinner than the control group), whereas in the nasal quadrant, 13 of 20 eyes (65%) had thicker pRNFL (mean: 6.85 µm, 95%CI, 1–13 µm; 9% thicker compared to the control group). There was no statistically significant difference in the thickness of the superior and inferior quadrants and the global pRNFL compared to the control group.
Conclusion: STGD is considered pathognomonic for the preservation of the peripapillary retina and retinal pigment epithelium (RPE), and is mainly characterized by RPE and photoreceptor cell loss in the macula. STGD was associated with thinning of the temporal quadrant, corresponding to the macular area in the pRNFL analysis. It is not yet known whether the RNFL loss is due to transneuronal degeneration or direct damage to ganglion cells resulting from degeneration of the outer retinal layers.

Keywords : ABCA4, retinal nerve fiber layer, spectral-domain optical coherence tomography, Stargardt disease, transneuronal degeneration

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Article available in :
Volume 3, Issue 6, 2024
Page : 130-135
https://doi.org/10.51271/ANKMJ-0030
Article Information
Received : 29 Ağu 2024
Accepted : 25 Eyl 2024
Published : 13 Kas 2024
Corresponding Author :

Ece Tuncel: Department of Ophthalmology, Ankara Etlik City Hospital, Ankara, Turkiye

[email protected]
Citation : Tuncel E, Çıtırık M, Yılmaz M. Is the peripapillary area completely healthy in Stargardt disease? Ank Med J. 2024;3(6):130-135.

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