ANKMJ
Ankyra Medical Journal

Ankyra Medical Journal (AnkMJ), formerly known as the Journal of Translational and Practical Medicine, regularly publishes international quality issues in the field of Medicine in the light of current information.

eISSN: 3023-655X
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Online Manuscript System

Index
Original Article
The impacts of contact lenses on the short- and long-term biochemical parameters of tear films and corneal thickness
Abstract
Aims: To investigate the effects of long- and short-term use of different types of contact lenses on corneal metabolism and corneal thickness.
Methods: The participants were divided into two groups in the study. In the first group, 20 of the 42 patients were administered a rigid gas-permeable lens (RGPL) with a Dk value of 92x10-11, while the remaining wore a soft contact lens with a water content of 38%. We then explored their Lactate Dehydrogenase (LHD) levels to evaluate the hypoxic effect on tear films in short- (8 hours) and long-term (2nd, 3rd, 5th months) and albumin levels to assess mechanical trauma. In the second group, the corneal thickness was measured using a Haag-Streit optical pachymeter before and at the 8th hour and 2nd month following the first set of lenses, and LDH and albumin values were simultaneously evaluated in tear film.
Results: The results yielded no significant increase in tear film LDH and albumin levels in the short- and long-term in both the RGPL and the soft contact lens groups with similar age and sex distribution. In the second part, the corneal thickness measurements resulted in an increase of 5.5% in the RGPL group and 3.63% in the soft lens group at the 8th hour of lens use. However, the groups did not significantly differ by baseline corneal thickness at the 2nd-month follow-up. Similarly, there was no significant increase in LDH and albumin levels in the tear film samples of the same group.
Conclusion: The absence of a long-term increase in corneal thickness and no elevated levels of albumin and LDH in tear films indicate that contact lenses fit corneal physiology.

Keywords : Lactate dehydrogenase, albumin, contact lens, hypoxia

Download Article


1. Stein HA, Slatt BJ, Stein RM. History of Contact Lenses. In:Fitting Guides For Rigid and Soft Contact Lenses. The C.V.Mosby Company, 3rd edition, St Louis, Ch. 15, 1990; p: 162-163.
2. White P, Scott C. Contact Lenses. In: Yanoff M, Duker JS, (ed.)Ophthalmology. London, Mosby, 1999; 2.11(1-8).
3. Güngör DİU, Erkan DD. Kontakt lensler: materyallerin fizikselözellikleri ve çeşitleri: derleme. J Exp Clin Med 2009; 21: 195-200.
4. Michima S. Corneal thickness. Surv Ophthalmol 1968: 13: 57-96.
5. Polse KA, Decker M. Oxygen tension under a contact lens. InvestOphth Vis Sci 1979: 18: 188-93.
6. Lyce SD, Beuerman RW. The effects of contact lenses on thenormal physiology and anatomy of the cornea. Curr Eye Res1985: 4; 719-22.
7. Lyce SD, Beuerman RW. The effects of contact lenses on thenormal physiology and anatomy of the cornea. Curr Eye Res1985: 4; 719-22.
8. Van Hearingen NJ, Glasius E. Enzymes of energy-producingmetabolism in human tear fluid. Exp Eye Res 1974; 18: 407-9.
9. Ichijima H, Ohashi J, Cavanagh HD. Effect of contact-lens-induced hypoxia on lactate dehydrogenase activity and isozymein rabbit cornea. Cornea 1992; 11: 108-13.
10. You J, Willcox MD, Madigan MC, et al. Tear fluid proteinbiomarkers. Adv Clin Chem 2013; 62: 151-96.
11. Runström G, Mann A, Tighe B. The fall and rise of tear albuminlevels: a multifactorial phenomenon. Ocul Surf 2013; 11: 165-80.
12. Bruce AS, Brennan AN. Corneal pathophysiology with contactlens wear. Surv Ophthal 1990; 35: 25-58.
13. Toft RA, Friend J. Biochemical aspects of contact lens wear. Am JOphthal 1975; 80: 139-45.
14. Van Hearingen NJ, Glasius E. The origin of some enzymes intear fluid determined by comperative investigation with twocollection methods. Exp Eye Res 1976; 22: 267-72.
15. Kahan IL, Ottoway E. Lactate dehydrogenase of tears and cornealepithelium. Exp Eye Res 1975; 20: 129-33.
16. Van Hearingen NJ, Glasius E. Lactate dehyrogenase in tear fluid.Exp Eye Res 1974; 18: 345-9.
17. Fullard RJ. Diurnal variations in human tear enzymes. Exp EyeRes 1984; 38: 15-26.
18. Sapse AT, Bonavida B, Stone W, Sercarz EE. Proteins in humantears. Arch Ophthal 1969; 81: 815-9.
19. Josephson AS, Lockwood DW. Immunelectrophoretic studies ofthe protein components of normal tears. J Immunol 1964; 93:532-9.
20. Fullard R. Tear proteins arising from lacrimal tissue. In: Principlesand practice of Ophthalmology. Ed: Albert DM, Jakobiec FA, WBSaunders Company, Philadelphia, 1994, p: 473-9.
21. Ichijima H, Cavanagh HD. Effect of rigid lens extended wearon lactic dehydrogenase activity and isoenymes in rabbit tears.Cornea 1994; 13: 429-34.
22. Doughty MJ, Jonuscheit S. Corneal structure, transparency,thickness and optical density (densitometry), especially asrelevant to contact lens wear-a review. Cont Lens Anterior Eye2019; 42: 238-45.
23. Khoramnia R, Rabsilber TM, Auffarth GU. Central andperipheral pachymetry measurements according to age using thePentacam rotating Scheimpflug camera. J Cataract Refract Surg2007; 33: 830-6.
24. Mandel RB, Polse KA, Fat I, Calif B. Corneal swelling caused bycontact lens wear. Arch Ophthalmol 1970; 83: 3-9.
Article available in :
Volume 1, Issue 3, 2022
Page : 68-72
https://doi.org/10.51271/JTPM-0019
Article Information
Received : 17 Eyl 2022
Accepted : 27 Eyl 2022
Published : 26 Ara 2022
Corresponding Author :

Çiğdem Ülkü Can: Health Sciences University, Ulucanlar Ophthalmology Training and Research Hospital, Department of Ophthalmology

[email protected]
Citation : Can ÇÜ, İrkeç M. The impacts of contact lenses on the short- and long-term biochemical parameters of tear films and corneal thickness. J Transl Pract Med. 2022;1(3): 68-72.

Read: 56
Download : 879
Cited: 0
_Footer