ANKMJ
Ankyra Medical Journal

Ankyra Medical Journal (AnkMJ), formerly known as the Journal of Translational and Practical Medicine, regularly publishes international quality issues in the field of Medicine in the light of current information.

eISSN: 3023-655X
Creative Commons CC BY-NC-ND 4.0 International License.
EndNote Style

Online Manuscript System

Index
Original Article
Exploring the antibiotic susceptibility of nosocomial infection causative Corynebacterium striatum strains
Abstract
Aims: Corynebacterium striatum (C. striatum) is one of the most frequently reported nosocomial infection agents among patients hospitalized in intensive care units following the COVID-19 pandemic. It may cause various opportunistic infections, such as ventilator-associated pneumonia and catheter-associated bloodstream infections, in such patients. The present study attempted to investigate the antibiotic susceptibility of 14 nosocomial infection agent C. striatum strains, isolated from deep tracheal aspirate and blood culture samples of hospitalized patients, for seven different antibiotics (benzylpenicillin, ciprofloxacin, clindamycin, rifampicin, linezolid, tetracycline, and vancomycin).
Methods: Antibiotic susceptibility of the strains for the mentioned antibiotics was determined utilizing a disk diffusion test in line with the recommendations of the European Antibiotic Susceptibility Committee (EUCAST).
Results: While all the isolated C. striatum strains (100%) were resistant to benzylpenicillin, tetracycline, rifampicin, ciprofloxacin, and clindamycin, we found none of them to be resistant to vancomycin and linezolid.
Conclusion: Overall, uncovering the antibiotic susceptibility of C. striatum strains isolated from clinical specimens would guide clinicians in deciding on the empirical treatment of hospital-acquired infections led by this agent.

Keywords : Nosocomial infections, Corynebacterium striatum, antibiotic susceptibility

Download Article


1. Santana GS , Silva CMF, Olivella JGB, et al. Worldwide survey of Corynebacterium striatum increasingly associated with human invasive infections, nosocomial outbreak, and antimicrobial multidrug-resistance, 1976–2020.
2. Garcia CM, Mckenna J, Fan L, Shah A. Corynebacterium striatum bacteremia in end-stage renal disease: a case series and review of literature. R I Med J 2020; 103: 46-9.
3. European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 6.
4. Zhang MJ, Cao XJ, Fan J, Yin ZG, Yu K. Corynebacterium striatum meningitis combined with suspected brain and lung abscesses: a case report and review. BMC Infect Dis 2020; 20: 389.
5. Tang J, Kornblum D,  Godefroy N,  Monsel G,  Robert J, Caumes E. Corynebacterium striatum thrombophlebitis: a nosocomial multidrug-resistant disease? Access Microbiol 2021; 3: 000307.
6. Agrawal SK, Khullar S, Srivastava A, Kapil A, Dhawan B. Corynebacterium striatum: an emerging nosocomial skin and soft-tissue pathogen. Natl Med J India 2021; 34: 88-9.
7. Kalt F,  Schulthess B,  Sidler F, et al. Corynebacterium species rarely cause orthopedic infections. J Clin Microbiol 2018; 56: e01200-18.
8. Orosz L, Sóki J, Kókai D, Burián K. Corynebacterium striatum-got worse by a pandemic? Pathogens 2022; 11: 685.
9. Rennie RP, Brosnikoff C, Turnbull LA, et al. Multicenter evaluation of the Vitek 2 anaerobe and Corynebacterium identification card. J Clin Microbiol 2008; 46: 2646-51.
10. McMullen AR, Anderson N, Wallace MA, Shupe A, Burnham CD. When good bugs go bad: epidemiology and antimicrobial resistance profiles of Corynebacterium striatum, an emerging multidrug-resistant, opportunistic pathogen. Antimicrob Agents Chemother 2017; 61: e01111-17.
11. Milosavljevic MN, Milosavljevic JZ, Kocovic AG, et al. Antimicrobial treatment of Corynebacterium striatum invasive infections: a systematic review. Rev Inst Med Trop São Paulo 2021; 63:e49.
12. Bläckberg A, Falk L, Oldberg K,   Olaison L, Rasmussen M. Infective Endocarditis Due to Corynebacterium Species: Clinical Features and Antibiotic Resistance. Open Forum Infect Dis 2021; 8: ofab055.
13. Neemuchwala A, Soares D, Ravirajan V , Marchand-Austin A, Kus JV, Patela SN. In vitro antibiotic susceptibility pattern of non-diphtheriae Corynebacterium Isolates in Ontario, Canada, from 2011 to 2016.
14. Abe M, Kimura M, Maruyama H, et al. Clinical characteristics and drug susceptibility patterns of Corynebacterium species in bacteremic patients with hematological disorders. Eur J Clin Microbiol Infect Dis 2021; 40: 2095-104.
15. Alibi S, Ferjani A, Boukadida J, et al. Occurrence of Corynebacterium striatum as an emerging antibiotic-resistant nosocomial pathogen in a Tunisian hospital. Sci Rep 2017; 7: 9704.
Article available in :
Volume 1, Issue 2, 2022
Page : 32-34
https://doi.org/10.51271/JTPM-0015
Article Information
Received : 25 Ağu 2022
Accepted : 14 Eyl 2022
Published : 30 Eyl 2022
Corresponding Author :

Salih Cesur: Department of Infectious Diseases and Clinical Microbiology, Ankara Training and Research Hospital, University of Health Sciences, Ankara, TURKEY

[email protected]
Citation : Ataman Hatipoğlu Ç, Cesur S, Kaya Kılıç E, et al. Exploring the antibiotic susceptibility of nosocomial infection causative Corynebacterium striatum strains. J Transl Pract Med 2022; 1(2): 32-34.

Read: 1202
Cited: 0
Download : 396
_Footer